Hepper is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Neo Daniff (Neapolitan Mastiff & Great Dane Mix) Info, Pictures, Facts & Care

Nicole Cosgrove Profile Picture

By Nicole Cosgrove

neo daniff

Height: 26 – 36 inches
Weight: 150 – 200 pounds
Lifespan:  7 – 11 years
Colors: Cream, brown, red, black, brindle, white, sable, fawn
Suitable for: Active families with children, house with a fenced yard
Temperament: Loyal, loving, intelligent, eager to please, friendly, gets along with other pets

The Neo Daniff has a unique name and a unique heritage. When you combine the Great Dane with the Neapolitan Mastiff, you end up with the Neo Daniff. Coming from two giant dogs will give you one huge dog with both parents’ best qualities. Loving and friendly but very mellow and protective, the Daniff is a low maintenance mixed breed.

These are large dogs that weigh an average of 150 pounds but could be as large as 200 pounds. They have short coats that come in a wide variety of colors but are rarely just one overall color. They tend to have large, squarish heads with floppy ears and long muscular legs.

Divider 1Neo Daniff Puppies 


The Neo Daniff is an active breed that enjoys exercise as much as napping. This dog breed is robust and generally healthy with an average lifespan expected for a large breed. They are intelligent dogs but are also stubborn, so training might be a bit of a challenge. They are protective of their family but are very social and friendly dogs with just about everyone they meet.

The Neo Daniff is a great fit for active families. They create strong bonds with their human companions, especially with children. They need plenty of space to run around in, so they might not be the best choice for apartment dwellers.

Divider 8

3 Little-Known Facts About the Neo Daniff

1. The Neo Daniff are excellent watchdogs.

They are protective of their family and will warn of any intruders (and their sheer size is enough to scare almost anyone away), but they make terrible guard dogs as they are friendly with just about everyone.

2. The Neo Daniff thinks it’s a lapdog.

They love nothing more than spending time with their family and cuddling up with their loved ones.

3. The Neo Daniff is easy and a challenge to train.

They are smart and eager to please but also have a stubborn streak. This makes the Neo Daniff both easy and challenging to train, depending on the dog’s temperament, of course.

Parent Breeds of the Neo Daniff
Image Credit: (L) Christian Mueller, Shutterstock | (R) Jumpstory

Temperament & Intelligence of the Neo Daniff 🧠

The Neo Daniff is a very eager to please and obedient dog that is loveable and friendly with just about everyone it meets. They love cuddling up with their people and are smart dogs that pick up training quickly.

The Neo Daniff is quite sensitive and does not like being left alone as they are prone to crying if left by themselves for too long. Their large size can also include some occasional clumsiness, but they are passive, sweet dogs that love nice long naps.

Are These Dogs Good for Families? 🏡

The Neo Daniff makes the perfect family dog. They get along very well with children and will protect the entire household from intruders. While they are great with children, there should be supervision with the little ones due to the size and occasional clumsiness of the Neo Daniff.

Does This Breed Get Along with Other Pets? 🐶 😽

The Neo Daniff gets along with all other pets without any known issues. When they protect the family from intruders, this includes all other pets, even the family cat. They are friendly and affectionate with everyone in the household and are even known to snuggle up with the cat.

Divider 4

Things to Know When Owning a Neo Daniff

Food & Diet Requirements 🦴

The basic food requirements for the Daniff are what should be expected for all large breeds. This will include 4 to 5 cups of dry dog food spread out over 2 or 3 times a day. Make a point of reading the instructions on the back of the food bag when you’ve found your dog’s perfect kibble. Also, check with your veterinarian if you’re ever concerned about your dog’s weight or health.

Exercise 🐕

The sheer size of the Neo Daniff requires a moderate amount of exercise. This will include about two long daily walks in addition to playtime and any other activities you might enjoy with your dog (including, but not limited to, swimming, hiking, biking, playing fetch, or agility trials). Your Neo Daniff will enjoy long naps after a good workout.

Training 🦮

The Daniff is a smart dog that is obedient but stubborn at times. They are fast learners, so training should come quickly but with some extra patience from the owner. Positive reinforcement, including rewards and lots of praise, will give you a very confident and happy adult dog.

Grooming ✂️

Grooming is easy thanks to the short coat of the Neo Daniff, which requires brushing only 2 or 3 times a week. Bathing a dog with a good dog shampoo is only necessary about once a month or when absolutely necessary as the dog’s coat’s natural oils are essential for keeping the skin from drying out and becoming irritated.

Other regular grooming habits should include brushing their teeth, trimming their nails, and cleaning their ears.

Health and Conditions ❤️

Minor Conditions
Serious Conditions

While mixed breed dogs aren’t as susceptible to these health issues as their purebred parents, your vet will run hip, elbow, skin, and cardiac exams for the Neo Daniff. Part of the physical exam will also include running blood and urinalysis tests.

Your vet will check your dog’s eyes, perform radiography, and run blood and urinalysis tests to help rule out these issues for your dog.

Divider 5

Male vs Female

One of the most obvious differences between males and female Neo Daniffs is in size. The female Neo Daniff can be 26 to 32 inches in height, whereas the male might be 30 to 36 inches. The female might weight about 150 to 180 pounds, and the male could run about 175 pounds to 200 pounds.

If you choose not to breed your dog, surgery is the next main difference between male and female Neo Daniffs. Spaying a female dog is a slightly more complex operation and is, therefore, a little more expensive and takes the female a little longer to recover from. The benefits of spaying or neutering your dog include reducing the risk of future health problems, and it decreases any aggressive behaviors and the instinct for your dog to run away.

Lastly, there are many that believe that there are differences in temperament between males and female Neo Daniffs. It is thought that females are generally more affectionate and less aggressive than males, but there are debates on this. The overall determination of most dog’s personalities is how they were raised as puppies and how they are treated as adults.

Divider 3

Final Thoughts

Both the Great Dane and the Neapolitan Mastiff belong in the Working Group and are giant and sweet breeds. This guarantees that the Neo Daniff will be a large, cuddly, and active dog that wants nothing more than to spend time with and protect its family.

As previously mentioned, there are no puppies available at the time of this writing, so if you’re interested in the Neo Daniff, you should start by talking to Great Dane and Neapolitan Mastiff breeders. Otherwise, you can also seek help from local and national dog clubs and attend dog shows as well as keep an eye on rescue groups in your area. Posting online through social media would be a great way to get your message across to a wider audience.

The Neo Daniff makes a wonderful family pet, provided you have the space to accommodate such a large dog. If you’re looking for a gorgeous dog to act as a family protector and to run with as well as snuggle up to, you can’t go wrong with the Neo Daniff.

Featured Image Credit: Pikist

Related Articles

Further Reading

Vet Articles

Latest Vet Answers

The latest veterinarians' answers to questions from our database