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Imodium for Dogs: Dosage and Usage (Vet Answer)

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By Dr. Samantha Devine

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Dr. Samantha Devine

Veterinarian, DVM

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Your dog has been keeping you up all night because they are dealing with diarrhea, and it’s still several hours before your veterinarian opens for you to call. You have Imodium on hand. Is that something you can give your dog, and if so, how much do you give?


What Is Imodium?

Imodium is the brand name for a medication called loperamide. In addition to being available as a generic, you can find it as:

  • Imodium
  • Anti-diarrheal
  • Diamode

Imodium treats diarrhea. It is used off-label or extra-label in dogs, which means it isn’t FDA-approved for them. You should only give loperamide if your veterinarian recommends it because it does have potential side effects.

Imodium slows gut motility by acting on smooth muscle in the gastrointestinal tract. In addition to slowing gut transit time, having more time in your dog’s gut allows your pup’s body to reabsorb water and nutrients, so the stool shouldn’t be as loose.

According to the Mayo Clinic, you should store the medication in a closed container, in a dry place at room temperature, away from excessive heat or cold and direct light.

imodium pills in rx prescription drug bottle
Image Credit: luchschenF, Shutterstock

How Is Imodium Given?

Imodium or loperamide is available in several forms: a liquid suspension, tablet, or capsule.

In its article on treating colitis in pets, the Merck Veterinary Manual lists the dosage for loperamide as 0.1–0.2 milligrams per kilogram of body weight, given every 6 to 12 hours.

It is best not to give loperamide except under the direction of your veterinarian. While it can help with diarrhea, it shouldn’t be used in cases of infectious diarrhea, such as intestinal parasites or Salmonella infections. Your veterinarian will need to perform testing to help determine the underlying cause.

What Happens if You Miss a Dose of Imodium for Your Dog?

If you miss a dose of loperamide, give it as soon as you remember. However, don’t give two doses together and wait the recommended period between doses (usually 6 to 12 hours).

pet owner giving pill medication to dog
Image Credit: Jus_Ol, Shutterstock

Potential Side Effects of Imodium in Dogs

The most common side effect of Imodium in dogs is constipation. This effect is especially common after multiple doses of Imodium, so your veterinarian will likely direct you to stop the medication as soon as your dog’s diarrhea stops.

Other side effects include the following:
  • Sleepiness
  • Bloat
  • Vomiting
  • Pancreatitis
  • Depression

Unfortunately, some dogs have a specific gene that makes them more susceptible to the effects of loperamide. These dogs have an MDR1 mutation or multi-drug resistance gene.

Certain breeds more commonly have this gene, such as:

These dogs are likely to experience toxic side effects from the loperamide.


Frequently Asked Questions (FAQs)

Why can’t dogs have Imodium?

Many dogs can take Imodium, but it should only be given under the supervision and advice of a veterinarian. Some dogs may have genetic sensitivity to the medication if they have an MDR1 gene, but it can also have side effects or drug Interactions for other dogs.

Will one Imodium hurt my dog?

While one Imodium tablet isn’t likely to hurt your dog if they’re a medium to large breed dog, you should still be careful when giving it. Unfortunately, it can be challenging to dose small dogs because the recommended dosage is about 1 milligram per 20 pounds. (A regular Imodium tablet contains 2 milligrams.)

dog takes the pill from the owner's hand with its paw
Image Credit: Aleksandr Finch, Shutterstock

What can I give my dog to stop diarrhea?

If your dog has diarrhea, you should have it examined by a veterinarian to ensure it doesn’t have something more severe than a soft stool. In the meantime, you can offer your dog a bland diet of chicken and rice or lean ground beef and rice.

Probiotics are often very beneficial for our dogs. A commonly used brand is Purina’s Forti-flora. For anxious dogs, Purina Calming Care can be a helpful probiotic.



It’s normal to want to reach for something in our medicine cabinets to treat our dogs, especially when they have bad diarrhea. While Imodium is generally safe, you should only administer it at your veterinarian’s recommendation.

Featured Image Credit: Creative Cat Studio, Shutterstock

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